A Comparative Analysis from a Tertiary Maternity Unit. NHS Imperial College Healthcare – NHS Trust, United Kingdom. British Maternal & Fetal Medicine Society. Presented at BMFMS2025 | Belfast
Dr Savannah Holness, Miss Sana Usman, Miss Marisa Taylor-Clarke, Professor Christoph Lees.
Background
Postpartum haemorrhage (PPH) remains a significant cause of maternal mortality and morbidity in the UK. According to the MBRRACE-UK 2024 report, obstetric bleeding accounts for 7% of maternal deaths, emphasising the critical importance of effective second-line interventions.
Objective
Evaluate the effectiveness of CELOX™ haemostatic agent versus balloon tamponade in controlling PPH through comparison across several clinical outcomes including:
• estimated blood loss
• haemoglobin drop
• transfusion requirements
• time to achieve haemostasis
Method
Comparative analysis of CELOX™ (n=12) versus balloon tamponade (n=17) in the management of postpartum haemorrhage at a tertiary maternity unit from January 2024. Statistical analysis was performed using Python. Independent t-tests were used to compare continuous variables between groups.
Conclusion
• CELOX™ is a promising alternative to balloon tamponade in PPH management , with comparable safety profiles, no worse outcomes identified
• Suggests potential advantages in blood loss control (22.5% reduction) and reduced transfusion requirements
• CELOX™ shows particular utility in vaginal wall trauma cases
• Cost-effectiveness offers additional compelling reasons to consider its inclusion in clinical protocols
• Further prospective evaluation with a larger cohort will better define optimal patient selection criteria, particularly regarding the differential efficacy observed between atonic and traumatic causes of PPH
• Ongoing evaluation of clinician experience will provide valuable insights into real world implementation challenges